What is tirzepatide?
Tirzepatide (also known as GIP/GLP-1 RA) is a synthetic peptide consisting of 39 amino acids with a C20 fatty acid modification. It simultaneously activates the GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptors, making it a next-generation dual receptor agonist.
Mechanism of action
Through the simultaneous activation of both receptors, tirzepatide enhances insulin secretion, improves insulin sensitivity via GIP-mediated pathways, and modulates appetite and energy expenditure through central and peripheral mechanisms. The synergistic effect of this dual activation results in superior efficacy compared to pure GLP-1 agonists.
Research findings
- Average weight loss of 20.9% after 72 weeks in SURMOUNT-1 (highest dose)
- Superior HbA1c reduction compared to semaglutide (SURPASS studies)
- Improvement in liver fat levels and cardiovascular markers
- Research on sleep apnea and heart failure
Technical data
| Sequence | 39 amino acids with C20 fatty acid modification |
|---|---|
| Sum formula | C₂₂₅H₃₄₈N₄₈O₆₈ |
| Molecular weight | 4,813 Da |
| Purity | ≥ 98 % (HPLC-tested) |
| Form | Lyophilized powder |
| Half-life | ~ 5 days |
| Storage | At -20 °C (long-term) or 2–8 °C (short-term) |
| Origin | Synthetic |
For research purposes only. Not intended for human use.
Reconstitution note 10 mg: This vial size is particularly suitable for shorter test series or as an entry point into a dose escalation protocol, as less substance is used per attempt.
Reconstitution: Example calculation
To achieve a working concentration of 10 mg/ml, reconstitute the 10 mg vial with 1 ml of sterile bacteriostatic water (BAC water). Slowly inject the water along the inside of the vial and gently swirl it instead of shaking. Detailed step-by-step instructions can be found in our user manual.
Frequently Asked Questions
How many trials can be prepared with a 10 mg vial?
Depending on the target concentration and dilution step, several sub-amounts for different experimental approaches can be taken from a 10 mg vial.
Is the 10 mg dose suitable for initial test series?
Yes — the smaller vial size reduces substance consumption in initial trials before larger quantities are ordered.
Quality assurance
Each production batch undergoes independent dual testing: HPLC analysis to determine purity and LC-MS analysis to definitively verify molecular mass and correct peptide sequence. Only after passing this test is a batch released.
Miriam ✓ Verified order –
I'm losing weight quite well as a result. I'm very satisfied.
Kim ✓ Verified order –
Unfortunately, I can't say anything about that yet.