Retatrutide 40mg

Retatrutide 40mg – GLP-1/GIP/Glucagon Triple Agonist

Retatrutide (LY3437943) is a triple hormone receptor agonist developed by Eli Lilly that simultaneously acts on GLP-1, GIP, and glucagon receptors. In the Phase 3 TRIUMPH-1 clinical trial (May 2026), Retatrutide delivered the strongest published weight-reduction data for any medication to date.

This 40mg vial is ideal for large projects and parallel trials with multiple dosage groups.

Mechanism of action

Through the simultaneous activation of three metabolic signaling pathways, Retatrutide exerts a synergistic effect on energy balance, insulin sensitivity, and fat loss. In the phase 3 TRIUMPH-1 trial (NEJM 2026), participants receiving the 12 mg dose lost an average of 25.0% of their body weight after 80 weeks. With 9 mg, the loss was 23.7%, with 4 mg 17.6%, and with placebo 3.9%.

Technical specifications

Storage: Store at −20 °C (long-term); after reconstitution at 4 °C, use within 2–4 weeks. Protect from light and moisture.

Source: Eli Lilly TRIUMPH-1 Phase 3 study, May 2026

Disclaimer: Not intended for human or veterinary use. For laboratory research purposes only. Not for diagnostic or therapeutic purposes.

Reconstitution note 40 mg: This vial size offers the highest yield per trial and is suitable for long-term trials with reduced reconstitution effort over the entire study duration.

Reconstitution: Example calculation

To achieve a working concentration of 10 mg/ml, the 40 mg vial is reconstituted with 4 ml of sterile bacteriostatic water (BAC water). Slowly inject the water along the inside of the vial and gently swirl it instead of shaking it to avoid damaging the peptide structure. Detailed step-by-step instructions can be found in our user manual.

Frequently Asked Questions

Who is the 40 mg dose suitable for?
The largest available vial quantity is suitable for long-term trials with reduced reconstitution effort over the entire study duration.

Can I use the 40 mg amount for several smaller batches?
Yes — after reconstitution, the stock solution can be divided into several subsets for different series of experiments.

Quality assurance

Each production batch undergoes independent dual testing: HPLC analysis (High Performance Liquid Chromatography) to determine purity and LC-MS analysis (Liquid Chromatography Mass Spectrometry) to definitively verify molecular mass and correct peptide sequence. Only after passing these tests is a batch released.